Recognizing the destructive power of its captive giant Ape, the military makes its own battle-ready A.I., Mecha Ape but its first practical test goes horribly wrong, leaving the military no choice but to release the imprisoned giant ape …

根据《惊声尖叫》系列电影改编，残忍谋杀案后引起的网络讨论唤起人们对过去杀人狂魔的记忆，引起某些人的好奇，也启发了新的杀人犯。两个老朋友和一群年轻人为此重新联系起来，他们互相成为恋人、敌人、冷血杀手嫌疑人、目标和幸存者。