A legendary dog trainer believes he can transform Marmaduke from an undisciplined, but lovable dog, into the first Great Dane to win the World Dog Championship.

《精灵旅社》系列大结局。一场意外使得精灵家族全员变身。为了避免身体永久互换，他们环游世界去寻找治疗方法，在人间开启了一段疯狂冒险，种种奇遇引发笑料不断。